I am working on column chromatography of Acrylonitrile monomer to remove its inhibitor, prior to polymerisation. I need some expert opinions about where I do wrong.
In the preliminary polymerisation trials, monomer conversion rate remained very low. For this reason, I am wondering what i do wrong.
Maybe, there is small amount of inhibitor left in monomer, so it affects the polymerisation and conversion remains low.
One of the questions is how column chromatography is successful to fully remove inhibitor from the monomer.
Procedure that I use:
I have 80g of Acrylonitrile, which contains 40-50 ppm monomethyl-ether-hydroquinone as inhibitor.
Column has 3 cm in diameter.
So, monomer height in column is more or less 15 cm.
Neutral alumina is used as stationary phase, and is 8 cm in height.
Speed of monomer flow is 1 cc per minute.
My questions about the process is
Is stationary phase height is low ? How can I determine it.
Should monomer flow be slower or faster ? How does this affects separation.
Thanks for the opinions and answers.
Dear Evren Toptop, the more simplest and efficient way to purify acrylonitrile is via distillation. Column chromatography is associated with many shortcomings, such high loss mainly for polar mobile phase, use of excessive solvent, strong effect of the stationnary phase pH, granulometry, path lenght, .... My Regards
Evren Toptop
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