Severe acute respiratory syndrome coronavirus 2, formerly known as the 2019 novel coronavirus, is a positive-sense single-stranded RNA virus. It is contagious among humans and is the cause of coronavirus disease 2019. I am trying design a model of multi epitope subunit based vaccine by immunoinformatics approaches.
You can do some epitope analysis using IEDB tool and then BLAST in NCBI.
Best of luck
Dear shahriar the model already designed by the research team of Cold Spring Harbor Laboratory. You can visit this website for getting very clear and appreciate answer of your questions.
https://www.biorxiv.org/content/10.1101/2020.02.04.934232v1.full.pdf+html
Why searching only for vaccines and medication? Yes ist is just to make money!
I am treating virusdiseases sinne ten years. sucessfully by an energetic provedure
it is cheap and easy to learn. But nobody is interested.
Hi,
you can have a look on my recent ongoing project "CoronaVIR": Computational web resource on Covid-19.
It has organised information related to coronavirus from literature and Internet. We have also provided additional link. In addition to peptide based vaccine, potential adjuvants candidates, RNA therapeutics, potential drug molecules we are also proposing potential primers for diagnostics. It is an integrated multi-omics repository dedicated to current genomic, proteomic and therapeutic knowledge about coronaviruses particularly the recent 2019-nCoV.
Sorry if I sound "stupid" but is there any way to predict wich antigens/epitopes are less prone to be affected by the viral mutations? Are these the target, or it may happen that the better target will be na antigen that may suffer mutational-induced changes?
Could this work? Here’s a method we might investigate, that might immunize people until we have the vaccine. 1) Collect blood from those who have recovered, and extract and stockpile their COVID-19 antibodies. 2) Administer the Coronavirus itself to patients we wish to immunize 3) Allow the virus to develop to a certain point within the patient, and: 4) Then administer the stockpiled serum to quickly cure them. 5) The patient recovers, and has developed their own immunity Thus, we ‘hack’ the virus, by activating the patient’s immunize system to develop the antibodies, and quickly cure them with antibodies stockpiled from recovered patients. If this process is feasible, we could use it as a bridge to protect our most vulnerable until we have a working vaccine. Could this work? Why or why not?
May be it works. But I do not Need vaccines I can treat infeted People within two minites and neutralize all viruses in their Body.
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