if there's any way of converting an in vivo dose e.g., 20 mg/kg in rat, into a concentration µM that can be used in in vitro assays, or vice versa.
Adam B Shapiro
The concentration in the rat plasma or tissue will change over tine following the dose, so there is not one single concentration to which to compare. Instead, you will have to measure the in vivo concentration as a function of time after dosing (pharmacokinetics). Then you will be able to compare the in vivo concentration at each time point to in vitro potency at that concentration.
2 votes
1 thanks
- Badges
- Science topic
More Sujoy Kundu's questions See All
Similar questions and discussions