How to calculate LADD (Lifetime average daily dose) for carcinogens??

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Sepehr Maleki

LADD = (Cw x IR x EF x ED)/ (Bw x AT)

Cw = Concentration

IR = Ingestion (eg) ratio

EF=Exposure Frequency

ED=Exposure Duration

BW=Body Weight

AT=Average time ( for carcinogens = life time (70 years eg) x 365 days

Irnis Azura Zakarya

Can i have the related paper on this calculation Sepehr Maleki

Thanks

Nihada Ahmetovic

See:

https://www.epa.gov/sites/production/files/2014-11/documents/guidelines_exp_assessment.pdf

Article Cancer Risk Assessment with Intermittent Exposure

http://www.columbia.edu/itc/sipa/envp/louchouarn/courses/env-chem/Risk%20Characterization%20Region%206.pdf

http://www.chec.pitt.edu/documents/Lecture4_ExposAssessDoseDefPart2.pdf