I have implanted a tumoral cell line subcutaneously in nude mice.
After intratumoral gene therapy treatment, a subgroup of mice develops ulcerated tumors.
Any idea how to avoid this?.
Hello Osmel Companioni Napoles
Ulceration may occur when tumors develop subcutaneously. The cause could be in situation where large tumors develop on the ventral surface and are subjected to constant abrasion, or sometimes these ulcerations could be caused due to the cell's origin type. There are cell lines that are predisposed to ulcerate.
I would suggest you change the initial tumor cell dose. Inject reduced cell number, and if ulceration is characteristic of the tumor line, you should try to complete the experiment in the latent period before ulceration.
Best.
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