Many times it is desired to use Brine shrimp toxicity assay for the evaluation of toxicity for any plant extract or drug formulation. What is its utility in place of conventional animal toxicological studies?
Dear Dr Sachan, some paper suggest that there is correlation between cytotoxicity and brine shrimp lethality in plant extracts. But is better using both bioassays
simultaneously as quality control. Other animal models very useful for toxicity in vitro testing are zebrafish and Caenorhabditis elegans, used for measure liver and kidney toxicity in zebrafish embryos. Such as aquatic toxicity testing. With best regards
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130034/pdf/1472-6750-2-17.pdf
http://rabatinscience.editme.com/files/Chapter-20-Envrionmental-Concerns/p1689.pdf
http://ir.library.oregonstate.edu/xmlui/bitstream/handle/1957/29408/JALA-MushfiqSarker.pdf?sequence=1
http://jhs.pharm.or.jp/data/48(6)/48_583.pdf
http://toxsci.oxfordjournals.org/content/106/1/5.full.pdf+html
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