How quickly are lentiviral vectors transported in the central nervous system?

19 January 2017 1 3K Report

I'm trying to estimate the amount of transport time needed to map out specific circuits in the spinal cord using a rabies-glycoprotein pseudotyped lentiviral vector. Does anyone know the kinetics of retrograde or anterograde transport for any lentiviral vectors? I've been trying to find information on this, ideally I'm looking for how many micrometers or millimeters/day these vectors can be transported through axons, etc.

Filippo Del Bene

Have you checked this paper? http://www.jbc.org/content/289/23/16148.long

It's a discontinuous process but can be very fast (0.2-1 um/s)

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