While educational research has generated a vast pool of studies and findings, much remains unclear and uncertain due to the complexity of linking learning with specific teacher actions for specific learners. Oftentimes future teachers express they want to be taught how to teach by learning THE best practice for instruction (including for assessment). In the absence of 100% certainty on what is known about teaching and learning, to what degree is it helpful to admit to them such uncertainty (which underscores the need for more research) and, at best, present to them multiple strategies and approaches that may be successful, depending on their context, the subject, and the characteristics and background of their learners?