How I can do the filtration of the reaction of APTES with hexanoyl chloride in presence of Et3N as base and chloroform as solvent?
Dear Mohamad,
The amino group of APTES reacts with hexanoyl chloride (nucleophilic attack) to form the hexanoyl amide of ABTES and chloride will be trapped by ET3N to form triethylammonium chloride. The next step should be evaporization of the chloroform to dryness, followed by dissolving the residue in dry ether, and filtration of triethylammonium chloride (not soluble in ether) using Whatman filter paper.
Hoping this will be helpful,
Rafik
Dear Prof Rafik,
i found that the product is not soluble in ethyl ether.
Dear Mohamad
Did u try to dissolve the residue in ethyl acetate instead of diethyl ether?
Dear talaat,
in fact i do not have ethyl acetate in the laboratory
thanks
Mohamad
Dear Mohamad,
You can try one of the following:
Benzene, Toluene or Dioxane. If the compound is not soluble in the three you can try THF.
Rafik
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