Why only sarcoid granuloma able to secrete vitD. While granuloma of tuberculosis and chrons disease generally do not secrete VitD.
Hello Dear,
Prolactin is frequently increased in sarcoidosis, between 3% and 32% of cases have hyperprolactinemia. this frequently leads to amenorrhea, galactorrhea, or nonpuerperal mastitis in women. It also frequently causes an increase in 1,25-dihydroxy vitamin D, the active metabolite of vitamin D, which is usually hydroxylated within the kidney, but in sarcoidosis patients hydroxylation of vitamin D can occur outside the kidneys, namely inside the immune cells found in the granulomas the condition produces. 1,25-dihydroxy vitamin D is the main cause for hypercalcemia in sarcoidosis and overproduced by sarcoid granulomata. For expanses details you can refer to:
https://medworm.com/422486988/association-between-vitamin-d-deficiencies-in-sarcoidosis-with-disease-activity-course-of-disease-a/
Best,
Kimia Taghavi
Hello Dear,
Prolactin is frequently increased in sarcoidosis, between 3% and 32% of cases have hyperprolactinemia. this frequently leads to amenorrhea, galactorrhea, or nonpuerperal mastitis in women. It also frequently causes an increase in 1,25-dihydroxy vitamin D, the active metabolite of vitamin D, which is usually hydroxylated within the kidney, but in sarcoidosis patients hydroxylation of vitamin D can occur outside the kidneys, namely inside the immune cells found in the granulomas the condition produces. 1,25-dihydroxy vitamin D is the main cause for hypercalcemia in sarcoidosis and overproduced by sarcoid granulomata. For expanses details you can refer to:
https://medworm.com/422486988/association-between-vitamin-d-deficiencies-in-sarcoidosis-with-disease-activity-course-of-disease-a/
Best,
Kimia Taghavi
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