Please have a look at this useful link.

https://www.cell.com/cell/pdf/S0092-8674(00)80042-2.pdf

Fluoxetine is an inhibitor of serotonin reuptake to incerase the level of serotonin in synapse cleft. Axons of serotonergic neurons are widely distrubuted in the entire cerebral brain, such that fluoxetine is acting onto numerous cells in the brain. Moreover, serotonin is one of neurotransmitters that maintain wakefulness through the ascending activating system in the brain stem. Fluoxetine may raise wakeful state instead of specifically improving low mood state in major depression.

Thank you Jin-Hui Wang,

But is there any useful literature that you can introduce.

Please have a look at this useful link.

https://www.cell.com/cell/pdf/S0092-8674(00)80042-2.pdf

Interesting query to me@ Seyed Sahand Mohammadi Ziabari

Thanks

Prozac (fluoxetine) is selective serotonin reuptake inhibitor (SSRI). It works by blocking the absorption of the neurotransmitter serotonin in the brain. It also results in more neurons being present in a region of the brain called the "dentate gyrus," part of the hippocampal formation.

Thank you Mahesh Kumar!

I ve also noticed that it suppressed the connection (LPT) between Hippocampal and PFC in a way.

Thank you Arvind Singh!

Hi, the references are given below. Thanks.

Thank you so much Jin-Hui Wang!