Methionine can be metabolized to homocysteine. Homocysteine level is increased by deficiency of folate, Vitamin B6 and12. I am just curious to know if there is any effect of Vitamin D on the level of homocysteine?
Vitamin D specially the 1,25-dihydroxyvitamin D(3) [1,25(OH)(2) D(3) is reported to be linked with a cluster of genes including the cbs gene, whereby the transcription process is more rapid and efficient. Moreover, . HCY is cleared from the serum by cystathionine β-synthase (CBS) enzyme through the the transsulfuration pathway and Vitamin D (1,25-dihydroxyvitamin D(3) is a major catalyst.
Hi,
I am also interested in this question. Would you know if there are epidemiological studies that have investigated the relationship between these two markers?
Thank you,
Monica
From a large community-based cohort of asymptomatic adults, it was found that there is an inverse relation between 25(OH)D and homocysteine among those with 25(OH)D concentration of 21 ng/mL or less. There wasn’t any observed statistical decrease in homocysteine once 25(OH)D concentration rose above 21 ng/mL.
Thank you Professor Ahmad. Do you know the name of the study or do you have a link to it?
I think I found the aforementioned study in asymptomatic adults (Amer 2014): http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913812/
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