Calcium Carbonate preparations create calcium oxalate which stores in the kidney and in long run causes the stone formation in kidney. Potassium citrate is used to treat/reduce the oxalate substances and stops further stone formation. Here in this mechanism, mainly citric acid (as citrate) shows the effect of reducing oxalate containing substances in kidney and prevents stone formation. I want to know is it be the same MOA for Calcium Citrate to show oxalate reducing effect as Potassium Citrate?
Moreover, patients having problem with acute renal failure and/or other renal complications are suggested to take calcium preparations as calcium citrate instead of calcium carbonate.
I'm going to launch a calcium preparation of [Calcium Citrate + Calcitrol] under Opsonin Pharma Ltd, Bangladesh.
That's why I need those supporting information.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1455427/
Dear Sir,
Citrate maintains acidic pH for longer and prevents crystallization of calcium salts and thereby prevents development of kidney stone.
Citrate is a powerful inhibitor of the crystallization of calcium salts.
Dr.P.A.Vora
Pharma COnsultant
AHmedabad, Gujarat, India
Pl. find attached herewith another article that may give you more clarity.
Dr.P.A.Vora
Pharma COnsultant
AHmedabad, Gujarat, India
Through acidification. Citrates prevent the crystalisation and therefore deposition of oxalate in the kidneys forming stones.
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