I have many clients that present with suboptimal ceruloplasmin and high levels on non-ceruloplasmin bound copper, with specific mental health symptoms. Aside from avoiding ceruloplasmin antagonists, how do you promote the production of ceruloplasmin?
Dear Johnny,
A method to promote an elevation of cerulopasmin is by inducing inflammation. It is believed that the increase in cerulopasmin levels due to inflammation is mediated by the hormone interleukin-1.
https://books.google.it/books?id=voHkBwAAQBAJ&pg=PA105&lpg=PA105&dq=promote+the+elevation+of+ceruloplasmin&source=bl&ots=8fujCPEgoq&sig=CI5_lGt949l6Rs2WMrOQGLXBVag&hl=en&sa=X&redir_esc=y#v=onepage&q=promote%20the%20elevation%20of%20ceruloplasmin&f=false
https://books.google.it/books?id=gELaBwAAQBAJ&pg=PA253&lpg=PA253&dq=promote+the+elevation+of+ceruloplasmin&source=bl&ots=tga5mBDfIS&sig=KHNZ7Mb8_zgdAgKAjfrPkzSPQfE&hl=en&sa=X&redir_esc=y#v=onepage&q=promote%20the%20elevation%20of%20ceruloplasmin&f=false
Hoping this will be helpful,
Rafik
That is interesting, except that inflammation triggers the kynurenine pathway that catabolises tryptophan and we end up with more problems than it is worth. many thanks
Dear Johnny,
Estrogen is another possibililty, eg in the form of contraceptive pills.
I do not think estrogen will trigger the kynurenin pathway, the ROS generation or the IDO-enzyme.
Best regards
Jan
Hi Jan, thanks for addresing the question. Estrogen will work, except it will also elevate copper levels, but it may be a good solutions as long as I block copper partially from rising. Many thanks
Hi Johnny,
Do you want to increase apo-ceruloplasmin ? Perhaps that will be impossible. The fraction of free copper is very small with or without estrogen.
Hi Jan,
Many of my clients have elevated free copper levels as a percentage. That is due to the fact that they have low ceruloplasmin levels as free copper is unbound. Free copper that is unbound as you will agree is very toxic. By elevating ceruloplasmin, I am hoping to lower the free unbound copper levels and chelate the reminder.
Dear Johnny,
The problem with low ceruloplasmin or even genetic aceruloplasminemia is not the non-ceruloplasmin copper (Cu++) that is bound histidin residues in albumin. Ceruloplasmin is a ferroxidase which keeps Fe in the trivalent state and bound to transferrin. Therefore, in cases of aceruloplasminemia the main problem is the iron deposits in brain regions accompanied by a peculiar kind of dementia that is different from Alzheimer's. ( I am aware of the papers by Rosanna Squitti who argues that 'free copper' represents a causative agent in Alzheimer's, but this is not consistent with other observations). Copper is taken care of by several other chaperones. Chelation With TRIEN should therefore not be justified, as far as I have understood..
Best regards, Jan
.
If you can lower copper levels presumably ceruloplasmin levels will increase?
VitC is the best way of lowering copper levels.
:-)
High levels of vitamin C in the presence of copper may promote Fenton reaction. I think an excess of histidin will chelate free copper, or histidin plus cysteine.
- Badges
- Science topic