How do specific long non-coding RNAs (lncRNAs) regulate androgen receptor (AR) signaling in prostate cancer progression?

Rashad Imad @Rashad-Imad

06 August 2025 1 9K Report

Epigenetic regulation
Chromatin remodeling
Cancer progression

Zhenglin He

Key lncRNAs modulate androgen-receptor (AR) signaling in prostate cancer progression via:

Blocking AR degradation (HOTAIR).
Stabilizing AR mRNA through direct RNA–RNA interactions (ARLNC1, PRCAT71).
Remodeling chromatin occupancy of AR transcriptional complexes (PCAT1).
Acting as miRNA sponges to relieve AR repression (MALAT1).
Regulating AR mRNA splicing, generating constitutively active AR variants (PCGEM1, FAM83H-AS1).

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