I have prepared a topical mosquito repellent patch by incorporating a volatile compound in it. The volatile compound is supposed to get released in to the environment. To obtain the release of volatile, the content of the volatile compound is determined at each time interval with the help of calibration curve. For example, at 0 hour the content is "X" and at 1 hour the content is "Y". Apparently the release of volatile compound at 1 hour will be =X-Y. Am I doing the right way or is there any other procedure to calculate it. Moreover, I do not know the exact procedure to calculate the cumulative % release of volatile. Someone please help.
You may (possibly) consider fitting some empirical correlation to the experimentally determined drying curve, in case you are not considering to model the system from a theoretical perspective. For instance, a very simple empirical correlation was that proposed by Rajan and Narayanaswamy (1986) ― but just considering drying (without skin absorption): http://onlinelibrary.wiley.com/doi/10.1002/cjce.5450640624/abstract
Hi,
Have a look at the literature below:
Microencapsulation of Oils: A Comprehensive Review of Benefits ...
onlinelibrary.wiley.com/doi/10.1111/1541-4337.12179/full
by AM Bakry - 2016 - Cited by 21 - Related articles
Nov 13, 2015 - Essential oils are volatile, complex mixtures of compounds .... by complex coacervation to achieve encapsulation efficiency of 99.6 wt% at an ...
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Spray Drying Techniques for Food Ingredient Encapsulation
https://books.google.com.au/books?isbn=1118864190
C. Anandharamakrishnan, Padma Ishwarya S. - 2015 - Science
10.3.1.2 Encapsulation efficiency of vitamins and polyphenolic compounds In the ... 10.3.1.3Encapsulation efficiency of flavors and other volatile compounds ...
]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]]
Encapsulation of Volatile Citronella Essential oil by Coacervation ...
waset.org/pdf/books/?id=14448&pageNumber=371
Abstract : The volatile citronella essential oil was encapsulated by simple ... methods in the present study produce encapsulation efficiency around 94%.
Dear Johirul,
I think your procedure is correct when your active matter can be volatile and not other components in ur final formulation....that means if some other components evaporated along ur active one u may consider total amount as ur active n thats why the procedure included some errors in this case....if u hv done enough experiments for constructing ur calibration curve ...I think yes you can do calculation by that...but make sure u hv enough exp. in ur cal. curve n first verify it by some unknown samples.....
Your method is correct. In this case as you have used the essential oil/oils as active ingredient, thus all amount of ai automatically becomes the active component. You can find out the rate of release after different time interval by estimating the amt released from or left in the patch. No need to determine the cumulative % release for this as total % release will serve the purpose.
Best
you can measure gravimetrically carefully the rate of evaporation at different condition and your composition also and can relate with your formulation
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