We are doing ester hydrolysis with NaOH. unreacted NH4Cl is also there in the reaction mass, which is used for earlier stage. During this ester hydrolysis we got 0.1-0.3% amide impurity. we want to control amide impurity as
Jack Silver
Prior to the hydrolysis, can you extract the salt (NH4Cl) by partitioning between water and an organic solvent? Or maybe do a solid-phase extraction of the ester while washing the ammonium chloride?
Alternatively, the acid and alcohol produced by the ester hydrolysis should have different retention than the amide on a chromatography column.
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