Maybe these articles are of interest.

https://www.eurekalert.org/pub_releases/2016-11/sri-trs111616.php

http://cancerres.aacrjournals.org/content/74/2/543.short

http://www.pnas.org/content/108/46/18790.full

https://www.eurekalert.org/pub_releases/2014-05/rumc-doc052114.php

https://medicalxpress.com/news/2012-08-molecular-link-circadian-clock-disturbances.html

https://lifehacker.com/how-your-circadian-rhythm-affects-your-health-1708492674

Regards,

Joachim

Huge question.

You my find these papers of interest since they answer, at least partly, to your question

all best

Thanks dear Yvan, ALAN sleep, mel, & chronodisruption Life Sci 2017.pdf (it is latest and very interesting review article).