I am actually working on pharmaceutical formulations with thermoplastic polymers such as "copovidone or Kollidon VA64 and active ingredients like "Paracetamol". When i was running DSC with pure polymers, i used to do heat-cool-heat cycle (25-250 at 10°C/ min) in order to obtain the glass transition temperature (103 °C). Now, I am producing extrudates of KVA64 with Paracetamol and I am trying to determine solid state change of the Paracetamol (which is crystalline and have melting peak at 170°C) and check if I obtained a solid amorphous dispersion. However, by applying the heat-cool-heat cycle method to the physical mixture or the extrudates, i only fitnd in the 2nd heat a glass transition temperature without the melting peak characteristic of the Paracetamol even though on XRD there a some cristalline peaks. I think during the 1st heating, I amorphized the Paracetamol within the copovidone and the 2nd heating displays the thermal profile of this in-situ solid amorphous dispersion and not my original product. Could you suggest me some solutions to this issue? Thanks in advance