I have a fairly large matrix (250*250) in symbolic form in MATLAB. Matrix is square invertible with size multiple of 2. I have to calculate the first two elements of the first two rows of its inverse (i.e. first 2x2 block). Matrix is very large and in symbolic form ,so, Matlab is not able to calculate the whole inverse due to time limitations. I have tried guassian elimination, LU factorization, block wise inverse technique. I have also tried the simple method of cofactors and determinent. In all the cases the problem is the same: very long time in the range of hours. Can anyone suggest some technique?

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