I'm doing a reaction in formamide and I have managed to remove nearly all of the solvent by roto-vap. Does anybody know any formamide azeotropes to allow me to remove the last traces of formamide? Any references would be greatly appreciated also
26 % Acetic Acid & Dimethyl Formamide form azeotrope as the Table, in the attached file, shows on page 5. My regards.
You mean formamide or dimethylformamide ? Because some answer are around dimethylformamide.
I think that you can add some base like Ca(OH)2 to increase the pH. In water with heath it will decompose and the HCN is trapped with the basic medium. After filtration you will have a clear solution.
compound take into diethyl ether and multiple wash with cold water defiantly it will remove. or make your compound salt in water and extract with organic solvents.
I agree with Professor Rossen Buyukliev . Azeotropic behavior requires (trying) if an azeotropic system is not listed in tables of references. When I was M.Sc. student, I knew that water/ethanol form an azeotrope but one of my professors said "Toluene & water form an azeotrope". My classmates & me were surprised, so he took us to the lab & demonstrated this to us collecting a "milky" toluene/water mixture in Dean-Stark apparatus.
I suggested Acetic acid/DMF above from a reference but since you meant formamide, then try to see if formamide forms azeotrope with acetic acid. You cannot predict azeotropic behavior based on "intermolecular forces" & the story above proves that.
your required product is water soluble? if no then formamide has a good partition coefficient in water inpresence of mild acidic medium. you can take your compound in organic solvent like toluene, heptane etc (perticulary aromatic hydrocabons) and give mild aqueous acidic wash preferably with acetic acid to remove formamide.
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