I had 2.5 M n-Buli in hexane, which can not be useful for the reaction. can any one suggest how to carefully quench large qty of it.?
Use the 2-propanol carefully. Drop the n-Buli slowly into cooled 2-propanol. Ice cooling is sufficient.
I agree with what Becker has suggested.
Please take care of the following three points related to safety:
- Please go through quickly the MSDS of n-butyl lithium (n-Buli)
- It is a pyrophoric compound (Normally available commercially as a solution in a hydrocarbon solvent)
- Lithium is a toxic element
I suggest you do not need to quench a large amount of n-BuLi. Itis very expensive and very reactive compound kepp it and use when need to strong base . Or ask somebody else to donate them. Otherwise you can of course quench with isopropanol adding drop by drop like other suggestions above.
To limit the formation of flammable butane react it with an ester to form a tertiary alcohol.
Add to excess of N-methylpyrrolidone under Ar (argon basin) by drop and mixing. Then add gradually water solution of sodium carbonate (to deposit insoluble lithium carbonate) . Hexane can be separated from both phases (not mixable with N-methylpyrrolidone and water), and rest is safe to remove into sewerage system.
This method was suggested (with sx) by me in Researchgate more than year ago for identical problem. No flammable butane evolution, toxic Li is in stable carbonate. Method is fast, safe and enviroment friendly.
Add to excess of N-methylpyrrolidone under Ar (argon basin) by drop and mixing. Then add gradually water solution of sodium carbonate (to deposit insoluble lithium carbonate) . Hexane can be separated from both phases (not mixable with N-methylpyrrolidone and water), and rest is safe to remove into sewerage system.This method was suggested (with sx) by me in Researchgate more than year ago for identical problem. No flammable butane evolution, toxic Li is in stable carbonate. Method is fast, safe and enviroment friendly.
This can be done by the addition of saturated aqueous ammonium chloride. The volume to be added should depend on the volume of n-BuLi used in the reaction.
thanks for your suggestions,
Ammonium Chloride is not freely available as it is in ban chemical.
large qty of n-buli require too much qty of it and we need to prepare saturated solution so cant think of Ammonium Chloride.
How can I separate LiCl from the n-BuLi Flask after the consumption of n-BuLi?
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