How can I phosphorylate primary alcohols in the lab?

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Jay Jha

Thank you so much Ali. Really appreciated it. I also found ways of phosphorylation by POCl3 and water. So I have 2 ways now.

Jarosław Lewkowski

For oridinary alcohols, the best way is to use phosphoric acid with DCC or other condensing agents. For serine, it will be to protect an amine and carboxylic group first then to make phosphorylation.