How can I perform a Michael Addition on a hindered a,b-conjugated system?

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What are the best conditions for a Michael addition?

I want to perform Michael addition (with O, N and S) to a a,b-conjugated system. I know that in the presence of copper, I can selectively have 1,4-addition. This works even in the presence of a...

04 May 2013 387 13 View

How can I tosylate an hindered secondary alcohol?

I'm trying to sterify with p-tosyl chloride (TsCl) a secondary alcohol. Although it is a simple reaction, it will not react, because the hydroxyl group is hindered. This group is located in a...

03 April 2013 8,513 59 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

16 June 2021 0 0 View

fatal error

16 June 2021 0 0 View

fatal error

16 June 2021 0 0 View

flexibility of polymers chain

effect of double bond on the flexibility of polymers

07 April 2021 0 0 View

Formulation of polymer color flakes

I am writing to request some information for making polymer color flakes. I would appreciate the help.

17 March 2021 0 0 View

Chlorinated organic formation in odor control scrubbers using hypochlorite?

I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...

03 March 2021 3,661 2 View

Resistor definition in Piezoelectric bimorph with ANSYS workbench

Hello, good day! I am trying to simulate similar bimorph piezoelectric harvester with below commands. However, the output power doesn't change with resistor value. Please help to find the reason. ET,10,CIRCU94,0 !SET UP RESISTOR R,1,100000 !RESISTANCE VALUE TYPE,10 !SET ELEMENT TYPE E,1,2 !CREATE RESISTOR BETWEEN NODES 1 AND 2 Thanks in advance Regards,

02 March 2021 0 0 View

Frank Kayser

This very much depends on what nucleophile you are planning on using... Assuming that you are looking for a C-C bond forming reaction, I have had good luck in the past with Mukaiyama-type additions, using a silyl enol ether in the presence of TiCl4. For organocuprates, Lipshutz' higher order cuprates are the way to go, see e.g.: Synlett (1990), (3), 119. Synthesis (1987), (4), 325. Tetrahedron (1984), 40(24), 5005.

Xin Zhou

This depends on what kind of hindrance your system owns, and the structure of the nucleophile.