I prepared UF microcapsules with epoxy resin inside it. I want to measure the rate of release of the core material.
Just put a known amount in a suitable medium. Take a lot of samples at the beginning to account for possible burst effect (zero time point, 15 min, 30 min, 1 h, 2h. 3h,4h,5h,6h 24 h, then daily till one week and weekly till you see no more coming out. Each sampling centrifuge the vials first, then take the supernatant (if 1 mL total take at least 0.8 mL to mimic sink conditions) and replace with fresh medium and re-suspend.
Good luck!
Agree with Roni Azaguri.
You can also put microcapsules in dialysis tube so that they are not mixed in whole dissolution medium. This will provide you freedom to take samples without removal of microcapsules, thus, sparing centrifugation step.
You will also need to construct as standard/calibration curve to find amount of drug in samples. Otherwise, you can dissolve core material in solvent in an amount that is present as core material in microcapsule you are using for release studies. Use it to find unknown concentration of samples.
If you need more information, please let me know.
Special dissolution technique can be adopted. Wherein, microparticles are to be placed tubes containing a suitable dissolution medium. The tubes are placed on a mechanical shaker with suitable experimental conditions. With different time intervals sample can be analyzed for the amount of drug released by suitable analytical method.
Special dissolution technique can be adopted. Wherein, microparticles are to be placed tubes containing a suitable dissolution medium. The tubes are placed on a mechanical shaker with suitable experimental conditions. With different time intervals sample can be analyzed for the amount of drug released by suitable analytical method.
Special dissolution technique can be adopted. Wherein, microparticles are to be placed tubes containing a suitable dissolution medium. The tubes are placed on a mechanical shaker with suitable experimental conditions. With different time intervals sample can be analyzed for the amount of drug released by suitable analytical method.
Special dissolution technique can be adopted. Wherein, microparticles are to be placed tubes containing a suitable dissolution medium. The tubes are placed on a mechanical shaker with suitable experimental conditions. With different time intervals sample can be analyzed for the amount of drug released by suitable analytical method.
Special dissolution technique can be adopted. Wherein, microparticles are to be placed tubes containing a suitable dissolution medium. The tubes are placed on a mechanical shaker with suitable experimental conditions. With different time intervals sample can be analyzed for the amount of drug released by suitable analytical method.
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