I am doing the coputation analysis of modified short peptides in AD. But I have no idea how to generate parameters for modified peptides. Any help will be highly appereciated.
If your modification corresponds one of the post-transnational amino acids then you can use the PTM server. The force field parameters are also given in this web server. follow the link: http://vienna-ptm.univie.ac.at/
There is a good server for it..LigParGen..it generates parameters using CM1 methods (quantum mechanics) and build the topology for a lot of force fields , also it has tutorials . I use it for OPLS .
If you want parameters for modified peptides you should use the tutorial of CHARMM for it..it's very good