In the second phase of Response Surface Methodology, using the central composite design on input/ output data, I want to fit a second-order polynomial on the subarea to find the optimum combination. Is there any mathematical formulation or toolbox in Matlab that can give me the estimated coefficients? I should code this in Matlab and do not want to use Minitab or Design

Expert software and I have four input data which makes it to estimate 15 coefficients.

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