you can not "dissolve" fat soluble material in water, you can only "disperse" or (if a liquid) emulgate it in water using a third component, then you will end up with an at least 2-phase, of not 3-phase colloidal system.

Some people may think or say that I am splitting words, but I don't. I suggest to use correct terms for certain phenomena. One would also not say "black" if something is white, or "plus" if in reality it is minus.

*solutions* and *dispersions / emulsions* are as much different as plus and minus, black and white, thermodynamic equilibrium and non-equilibrium systems.

It should dissolve in DMSO

A DMSO soluble drug administered in mice through i.p route has no problem like toxic effect. But to be sure check before hand the ld50 value of the solvent in the mice model you are working with.

Please find attached some relevant papers:

http://www.pdiconnect.com/content/29/1/5.full

http://www.ncbi.nlm.nih.gov/pubmed/17887122

http://daactarbhatti.weebly.com/uploads/3/5/1/6/3516207/absorption_of_drugs_by_dr._soban.ppt.

http://www.ualberta.ca/~csps/JPPS8%282%29/C.Rangel-Yagui/solubilization.htm

Good luck!

you can not "dissolve" fat soluble material in water, you can only "disperse" or (if a liquid) emulgate it in water using a third component, then you will end up with an at least 2-phase, of not 3-phase colloidal system.

Some people may think or say that I am splitting words, but I don't. I suggest to use correct terms for certain phenomena. One would also not say "black" if something is white, or "plus" if in reality it is minus.

*solutions* and *dispersions / emulsions* are as much different as plus and minus, black and white, thermodynamic equilibrium and non-equilibrium systems.

For Hosein Abtahi

Sticking to your query “Which of detergents or solvents are safe”---, I , very humbly, reiterate that DMSO is oftenly used as a safe solvent for drug administering in mice through i.p route.

What about free of fat-BSA?. I have used when working with lactic acid bacteria with vert good results.