You'd better decrease MW by chemical cleavage. Here the best option can be using hydrochloric acid (Article Kinetics of Hyaluronan Hydrolysis in Acidic Solution at Vari...
). Enzymatic cleavage makes the process more complicated. You'll further need to purify water soluble fraction from enzyme(s).
At the beginning think over the MW you'll need. Cause, while obtaining microspheres cross-linking with other reagents, MW will surely become greater.