Hello there, how are you? I do have a friend working a clinical Nutrition research which is rare to our country and specifically localized to Neonatal ICU. There are a few articles which is directly related to what his is working on but as the result of most of these articles are an observational study he couldn’t get the raw data of exposed and unexposed group or two by two table or something like that to calculate the sample size by using double population formula. He is ask you for your suggestion or ideas what should he do to get a minimum sample size from those papers in reach of these problem.
You might consider using Harvard's online sample size calculator which, as I understand, was created with support from NIH General Clinical Research Program. Available at following address: http://hegwig.mgh.harvard.edu/sample_size/size.html. Several design options available in this calculator. Suspect that "parallel trial where the outcome is a measurement" would be appropriate for cohort study as opposed to "study of the effect of one variable on another" which seems appropriate for randomized trial.
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