Leo Y T Chou
Baranya,
Elimination through the body typically occur through either metabolism or excretion. Nanoparticles are no exception. Non-biodegradable materials such as silica are minimally metabolized by the body and can only be excreted either through urine or feces. Renal clearance depends on the size as the filters in the kidneys have very stringent restrictions on the size of the molecule that can pass through to the bladder. Anything larger than the renal size threshold typically end up in the liver and spleen. Fecal excretion is more complicated and unpredictable, starting with liver processing and involves the bile as an intermediary point of storage and transfer to the GI.
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