Can a neuroprotective agent work as antioxidant?

Like all compounds with unsaturated bonds it would be prone to reacting with and therefore scavenging oxidizing free radicals.

As oxidative stress is a major cause for neuronal death it would be neuroprotective by reducing oxidative stress.

Hi Sanae Sabout

Some reported mechanisms by which 5-MTX exerts it antioxidant and neuroprotective effects according to literature are:

• Free Radical Scavenging: Similar to melatonin, 5-MTX might directly scavenge free radicals, preventing them from damaging cells.
• Enzyme Induction: It could induce the production of antioxidant enzymes that neutralize free radicals within cells.
• Membrane Protection: Some studies suggest 5-MTX might interact with cell membranes, influencing their fluidity and potentially reducing free radical-induced damage. However, the details of this interaction are not fully understood.

Thanks,

Samir Ranjan Panda thank you