We would like to either calculate CDI for different monthly periods after birth or for period of 1 year after birth for measured POPs concentrations in human milk. Would you recommend to use a traditional risk assessment approach for calculation of CDI, thus “CDI = C x IR x EF x ED / BW x AT” or would you alter the equation in some way? There are articles using just the following equation “CDI = C x IR / BW” however they do not take into account length of exposure and they produce significantly different results.
Hello Anna. I read your question and wondered if the use of the traditional risk assessment approach is the best means of addressing the issue. It's not completely clear to me from your question what you would like to achieve by calculating the risks, but I would emphasise that using the risk assessment approach you mention will probably give you very conservative estimates of risk related to these chemical exposures. I would highly recommend that if you want to calculate realistic (i.e. non-conservative) estimates of risk, you should consider using epidemiological data to support your assessment i.e. calculate the attributable risk associated with exposure to these POPs using odds ratios (or relative risks) from epidemiological studies. Although the exposures and outcomes are different, I wrote a paper about how and why to use epidemiological data in support of risk assessment. I hope it's helpful.
Article Assessing the human health impacts of exposure to disinfecti...
Hi Anna,
We have previously calculated actual daily intakes using formula in the paper attached. I hope it helps.
Zoya