I am interested in getting pure molecules with free thiol but the problem is that during the synthesis I always get a mixture of free thiols and disulphide bridge. After the purification on silica, all the thiol is oxidizide and I don't get any free thiol function.
Is there any other way to purify it?
I should add that both, the molecule with free thiol and disulphide bridge, are very apolar.
Thank you.
Yuri Mirgorod
Dear
Tanya Sahyoun
Do you need to vacuum distillation under a nitrogen atmosphere.
Best regards.
1 votes
0 thanks
Tanya Sahyoun
I need the free thiol form, and actually I tried adding 2-mercaptoethanol for the reduction but again once I'm done I can't separate it from my product in order to get pure thiol.
0 votes
0 thanks
- Badges
- Science topic
- Similar topics
- Chemistry
- Sulfites
- Inorganic Chemistry
Similar questions and discussions