My personal experience is only mastectomy and autologous reconstruction After neoadjuvant XRT. I fear increased complication rates (e.g. skin necrosis). A study is planned at University Düsseldorf - Dept. Radiotherapy.
Interesting question. Most would use chemotherapy as neoadjuvant treatment for loco-regionally advance/ triple negative/ Her2 positive/ large (compare to breast size) cancer wanting breast preservation. I have not used neoadjuvant radiation. I would like to know about it more!