We are examining whether density measurements could be a cost effective way of measuring concentration and homogeneity of pharmaceutical suspensions. If so, what is the sensitivity of the technique, and are the measurements reproducible?
Kamal Jonnalagadda
Prediction of stability via bulk density measurements is possible if bulk density of suspension is predictive of the density gradient. Density gradient is the difference in density between density of the suspended particles and the density of the bulk solvent. This would require that the density of the particles is known, and stays constant during the time scale of the study.
homogeneity on the other hand is a different issue. I would really like some type of light scattering data for these predictions.
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