I’m exploring whether consciousness can be experimentally modulated or disrupted through targeted interference with protein-level fluctuations or thermo-qubit dynamics, specifically under conditions of entropic loading and scale-dependent energy flow.
Theoretical models (e.g., Dynamic Organicity Theory, ODTBT) suggest that brain states emerge from multiscale thermodynamic processes, where fluctuations in molecular structures (like membrane proteins) help shape oscillatory coherence across neural networks.
From this view, consciousness is not static, but dynamically tied to oscillatory phase coherence, and potentially elevated through negentropic processes. This implies that entropic scaling (e.g., energy density across molecular to network scales) could influence the brain's transition into higher-frequency oscillatory states (e.g., alpha → gamma), or conversely, disrupt integration when coherence is lost.
My central questions:
- Have there been experimental investigations into how manipulating protein conformational dynamics or quantum-thermal fluctuation regimes (thermo-qubits) affect consciousness?
- Has anyone explored whether entropy gradients or energy scaling conditions contribute to the elevation or degradation of brainwave states?
- Are there studies that combine molecular dynamics, thermodynamic modeling, and EEG/MEG tracking to correlate biochemical shifts with phase-state transitions in neural activity?
Any leads on empirical work, experimental setups, or cross-disciplinary studies are welcome, especially those connecting biophysical fluctuation, entropic thresholds, and neural synchronization to shifts in consciousness.
Hi John,
I studied loss of consciousness. It can be induced by serotonin (from median raphe nucleus) which activates claustrum that induces slow waves in cortical and subcortical regions leading to loss of awareness and anesthesia. MRN and interpeduncular nucleus IPN induce loss of awareness by inhibiting the theta state and arousal promoting circuits (i.e. subsets of basal forebrain, LC, LH, PH, MS/vDBB, SUM, VTA, NI, LDT, PPT, vPAG.
For consciousness is important prefrontal cortex, working memory, basal forebrain, dopamine, and some thalamic nuclei.
Dear Karin,
Thank you for your detailed and helpful response, it’s exactly the kind of neurophysiological specificity I was hoping to surface. Your point about serotonin-induced activation of the claustrum and the role of the MRN/IPN in suppressing theta states is interesting.
I'm intrigued by your mention of how these structures modulate arousal-promoting nuclei like the basal forebrain, VTA, and medial septum. From the standpoint of a model I am developing, ODTBT, these circuits can be interpreted as coherence regulators operating across nested phase hierarchies. When they inhibit theta and gamma alignment, the system undergoes what the model distinguishes as Threshold Waveform Interface for State Change (TWIST), which is a recursive coherence collapse that in this case appears to be the interface for altered or unconscious states.
Your framing reinforces the idea that consciousness is not a binary state, but a transductive geometry, a structure that can be reconfigured through entropic flow and phase disruption at multiple biological scales.
If you know of any further studies that empirically map protein-level thermodynamics or phase gating structures to EEG coherence or entropy modulation, I’d be deeply interested.
Thank you again, your contribution greatly advanced the scope of my inquiry.
Warm regards,
John