Part 1 – Technical Feasibility "With current and emerging genetic engineering tools such as CRISPR-Cas systems, synthetic biology, and epigenetic modulation, is it theoretically possible to alter specific DNA and RNA sequences in humans to achieve physiological resilience and adaptability for long-term survival in extraterrestrial environments, such as the Martian surface or other planetary bodies with radically different atmospheres, gravity, and radiation exposure?"
Part 2 – Evolutionary Implications "If such artificial genomic modifications prove feasible, would this necessitate a fundamental re-evaluation of the Darwinian model of evolution as the sole explanatory framework for human adaptability? Could the capacity to engineer survival traits for non-terrestrial environments suggest that our genomic structure may be more flexible than previously thought, or even hint at alternative evolutionary influences beyond Earth-based natural selection?"
The problem is not CRISPR-Cas but the detection of changes that are needed to survive in different environments. Up to now, nobody knows what to change in human DNA. My opinion is, it is nonsense to ask this.