In cross-validation, which is the AUC population parameter I really want to estimate?

06 February 2017 4,359 6 View

Which Bootstrap for Confidence Interval of AUC with Leave-Pair-Out-Cross-Validation?

I have to calculate the CI of the AUC (Roc) for a series of classifiers (e.g. Lasso, Random Forest, SVM) learned using the same test dataset, in order to identify the best model for this problem...

20 December 2016 6,272 3 View

What are Arrhenius arguments "on the influence of Carbonic Acid in the air upon the temperature of the Ground"?

02 December 2015 2,907 24 View

How can I calculate a multi-centric ICC (intra-class correlation) variation before and after an agreement training?

Hi and thank you to everybody. I have data regarding a training that aimed to improve the agreement among raters. Raters gave a dichotomous judgment (presence/absence).The study is multi-centric:...

29 June 2015 5,851 3 View

If I pre-stain antibodies with Coomassie Brilliant Blue, would they work? Or will I end up covering the recognition portion and lose specificity?

I had this idea to use the stained antibodies in a lateral flow assay, Coomassie should make it easier to recognize the bands, better than gold or latex nanoparticles. Has anyone tried this before?

22 June 2015 3,805 3 View

No title

I have to compare the mean levels of a continuos variable y (ranging 1-20) subdividing my sample in two groups according to a dichotomous variables (i.e gender). Sample sizes of the two groups are...

08 April 2015 9,395 4 View

What do you think is the most correct procedure for Socio-demographic covariates in regression models and neuropsychological tests?

18 September 2014 4,849 3 View

Intra-class correlation: any test to statistically compare its increase?

I have to compare two ICC calculated by the same three judges on the same sample of subjects (presence/absence of a certain physical dysfunction) after and before a training to improve the judges'...

12 February 2014 3,673 6 View

Does the pressure(-600 mmHg) affects pH?

When I conducted the degassing experiment using decompression under anaerobic condition(and I used ferrous based chelating agent), the oxidized ferric were observerd. So, could you tell me the...

03 March 2021 4,892 5 View

What is the production process of CaFe ferroalloys?

I looking for ferro calcium production process

03 March 2021 1,755 4 View

What SPSS analysis should I run with one IV (with two levels) and two DVs?

Hi, I am trying to figure out which test would be most appropriate to run for the following question: Is there a difference in task blood pressure between smokers and non-smokers? There are two...

01 March 2021 8,235 2 View

Can water be extracted from Olivine?

I have always been interested in geology and wondered about how unique structures of materials behave in different circumstances. I stumbled upon Olivine, the magnesium iron silicate, and heard...

28 February 2021 7,330 4 View

Mediation path analysis - Can I run two seperate models?

I am wanting to run a serial mediation model with 2 x IVs, 2 x MVs, and 3 DPs (all continuous). Is it problematic to run 2 different models for each IV, keeping the MVs and DPs the same in each...

27 February 2021 5,681 3 View

How to calculate Ligand-active site distance in a ligand-protein complex from MD simulation?

I have run a MD simulation of a ligand-protein complex in GROMACS using CHARMM forcefield. Reviewer has asked me to calculate Ligand-activesite distance and binding free energy of ligand with...

27 February 2021 4,703 1 View

SEM or Multiple Regression for an analysis without Latent Variables?

Hello, I have three hypothesis to test, all with the same IV. I am testing if the effect of the IV on the first DV is mediated by awe. I am then measuring whether the effect of the IV on a...

26 February 2021 8,399 5 View

How does charge on working electrode changes with rising potential?

During performing CV of a GCE or modified GCE, we rise the potential in the first half of the cycle and reduce it in reverse half. During the first half, what is the nature of charge on GCE or...

25 February 2021 7,994 3 View

Are there lab markers/pens resistant to Roti-Histol?

Hi, I'm looking for a pen/marker to write on the smooth, transparent (non-frosted) part of microscopy slides which does not get washed away by alcohols and most importantly Roti-Histol. I want to...

24 February 2021 9,902 5 View

Why anti-CD20 or other antibodies are not used to label target cells in flow cytometry t-cell cytotoxicity assay?

New to the field of cell therapy. Why fluorescent-labeled antibodies to target cell antigens are not used for determining target cell count by flow cytometry in cytotoxicity assay (eg car-t)? Cell...

21 February 2021 3,278 3 View