Do you have to provide a feasible route from each starting molecule, or do you have to identify a (/the most) suitable one? Do you have any ideas yourself how it could be done?
OT: What is the target molecule used for?
Wolfgang Schechinger would be best to chose the easiest and quickest route as I have to replicate the reaction in the laboratory. I honestly have no idea I’m struggling to find any papers online which provides the exact reaction.
I don’t know what it’s used for and that’s not important to be honest , I just need to come up with a good synthetic route and a good lab protocol so I just produce it in the lab
Try https://pubmed.ncbi.nlm.nih.gov/?term=-5-oxopentanoate and look for Methyl (2S)-2-{bis[(tert-butoxy)carbonyl]amino}-5-oxopentanoate
Wolfgang Schechinger no results, the IUPAC name for the product is too long so I’m not surprised
With the link I have provided, I get at least 2 promising hits.
Zoltan Kaleta Thank you so much for your help, this paper is very helpful, the only issue i have is that for step 1 of the reaction as described on page S3 i cannot leave the reaction running for 14 hours. I only have 5 hours for each one of my lab sessions and therefore i must complete the esterification of l-glutamic acid in 5 hours. would you have any suggestions as to how I can work around this ?
Reactions which are reportedly run for 14 hours frequently are just sitting on the bench from 6pm to 8am. I would not be surprised if it is completed in a much shorter time. Should be easy to follow by DC or HPLC. However, I'd recommend completing the amino protection first, in order to avoid nasty surprises.