Tuberculosis is a public health problem, causing noteworthy morbidity and mortality. The pathogenesis is very different from other Infectitious diseases. Highly sensitive, specific, easy, cost-effective diagnostics is the need of the day.
Past tuberculosis diagnostics relied on sputum smear microscopy, which had limited sensitivity. Present methods include GeneXpert and culture-based tests, offering quicker and more accurate detection, including drug resistance. However, access and affordability remain challenges. Future diagnostics aim for point-of-care, non-sputum-based, rapid tests with higher sensitivity for early and latent TB detection.
I have published several papers describing certain tuberculosis diagnostics which are simple, less time consuming, specific, cost-effective, at point of care study, certainly reproducible. Those will not only diagnose all types of tuberculosis ,pulmonary or extra -pulmonary at the earliest including the latent one, but also be helpful to monitor the effects of anti-TB drug treatment as well as to diagnose drug resistant tuberculosis cases at the earliest. I request you all to please go through those papers and put your valuable critical observations.
Modern TB diagnostics (GeneXpert, culture, genomics) are far more sensitive and specific than traditional microscopy, but accessibility and cost remain major barriers. The future lies in affordable, point-of-care tests for early, latent, and drug-resistant TB