I am trying to esterify the amino acid (alanine) using butanediol or glycerol. Is there any possible route for this synthesis method? Can someone please suggest the temperature and catalyst for this reaction?
You may try immobilized lipase to esterify alanine with butanediol or glycerol in a water free reaction mixture.
There is no clear answer. You must decide if you will remove water during the reaction or not. You need to check if the alanine dissolves in butanediol or glycerol. The catalyst may be H2SO4 e.g. 0.025 wt%, but it can be different. - Many choices in front of you.
Thank you all for your answer. I want to remove water during the reaction. Regarding the solubility, I checked that excess glycerol or butanediol is needed for dissolution of alanine. Then How can I remove excess glycerol or butanediol ?
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