Does gender really matters, when it comes to the toxic effects of arsenic exposure in human beings.
Not only arsenic exposure. What about gender influence on other types of metal poisoning?
I have read in some research articles wherein it has been mentioned like males are more susceptible as far as toxic effects of arsenic are concerned.
Exposure to As leads to an accumulation of As in tissues such as skin, hair and nails, resulting in various clinical symptoms such as hyperpigmentation and keratosis. There is also an increased risk of skin, internal organ, and lung cancers. Cardiovascular disease and neuropathy have also been linked to As consumption. https://www.epa.gov/sites/production/files/2014-03/documents/human_health_effects_from_chronic_arsenic_poisoning_3v.pdf
Long-term exposure to arsenic from drinking-water and food can cause cancer and skin lesions. It has also been associated with cardiovascular disease and diabetes. In utero and early childhood exposure has been linked to negative impacts on cognitive development and increased deaths in young adults https://www.who.int/news-room/fact-sheets/detail/arsenic
Ingesting high levels of arsenic can result in death. Arsenic has also been linked to increased risks of cancer of the lung , skin , bladder , liver , kidney , and prostate . Symptoms of acute arsenic exposure generally occur within 30-60 minutes after ingestion. https://www.winchesterhospital.org/health-library/article?id=120795
I have read in some research articles wherein it has been mentioned like males are more susceptible as far as toxic effects of arsenic are concerned. But, no valid reasons were provided in connection with the above statement.
Yes I'm really curious of the fact that males are more prone to arsenic poisoning. Is it because of testosterone or because males are more exposed to arsenic than females.
Studies have reported an association between maternal exposure to elevated arsenic levels in drinking water and low birth weights, neonatal death, and infant mortality.
Dear P. Ravikumar many thanks for your very interesting technical question. In fact, there are gender and age differences in the metabolism of toxic arsenic in the body. For more information about this problem please have a look at the following relevant study:
Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh
Article Gender and Age Differences in the Metabolism of Inorganic Ar...
More general information about this issue can be found in the following article:
Gender differences in the disposition and toxicity of metals
Article Gender differences in the deposition and toxicity of metals
There is another interesting article which is freely available as public full text:
Gender difference in arsenic biotransformation is an important metabolic basis for arsenic toxicity
https://assets.researchsquare.com/files/rs-252094/v1/9ce9b1ef-1553-488f-bff3-a38723a45fb3.pdf
(see attached pdf file)
yes male reproductive system getting affected increasing amount of arsenic in water consumption. for more read this article
Article Arsenic Toxicity in Male Reproduction and Development
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