The paracellular pathway is a passive transport mechanism that involves the movement of substances across the luminal and abluminal membranes of the brain microvascular endothelial cells (BMECs)
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. This pathway is restricted due to the formation of tight junctions between the endothelial cells, which effectively eliminate paracellular transport across the BBB
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. However, small lipophilic molecules can passively diffuse across the lipid bilayer, and in many cases, are returned to the blood by efflux pumps
Then If passive transport is restricted due to tight junctions then how passive transport facilitate the delivery of drug across BBB
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