The answer to this is "Yes, almost certainly" If you are administering antibiotics, usually intravenously, to try to eradicate biofilms on stents, then most of the antibiotics will affect the rest of the body, including the skin, gut and mucous membranes, selecting for resistance and reducing resident "beneficial" flora. Use of antibiotics to eradicate biofilms is not feasible without stent removal.

Dear Nikolay:-

As you know Enterococcus faecalis and Enterococcus faecium strains isolated from biliary stents have been investigated for plasmid content, sex-pheromone response, presence of genes encoding for aggregation substance and adhesive properties. Virulence genes encoding for aggregation substance have been detected by polymerase chain reaction and the ability of clinical isolates to adhere to in vitro cultured cells and to produce biofilm, as well as their susceptibility to various antibiotics, has been assessed. This study indicates that the production of slime exhibited by most enterococcal isolates plays an important role in the colonization and subsequent occlusion of biliary stents, suggesting that aggregation substance is implicated in the occlusion process and that enterococci carrying aggregation substance genes have a selective advantage in endoprosthesis colonization

The cytotoxicity of the antimicrobial agents depends on the case by case. It depends on the composition of the bacterial cell wall.

I agree with Prof. Mushtak T. S. Al-Ouqaili

The answer to this is "Yes, almost certainly" If you are administering antibiotics, usually intravenously, to try to eradicate biofilms on stents, then most of the antibiotics will affect the rest of the body, including the skin, gut and mucous membranes, selecting for resistance and reducing resident "beneficial" flora. Use of antibiotics to eradicate biofilms is not feasible without stent removal.

Following article will be helped to you.

Thank you.