Hello all,
My question is whether positron emission tomography measures the binding of the radioligand to a receptor that is specifically located at the cytoplasmic membrane or to all receptors regardless where they are located in the cell. I guess it depends on the tracer physiochemical characteristics, whether it penetrates the cellular membrane or not, and on the binding site within the protein. I just need a confirmation from an expert.
Thanks
You are correct. The tracer is going to bind to all receptors regardless of their location if the physiochemical characteristics of the tracer allow it to do so. Theoretically a tracer can be developed to only bind at / within specific locations and structures, but you would likely need to work with experts to develop a new tracer for this.
Yes, positron emission tomography measures the binding of the radioligand....regardless its location. The location depends on the properties of the radioligand and/or its receptors/transporters etc...
Furthermore, due to the resolution of PET you could not differentiate the binding site in a cell........
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