Ozone/oxygen combination is used in the treatment of knee joint pain.
The reason for the favorable effect of ozone is the creation of ROS, but oxygen therapy does not create this compound.
Can oxygen alone have a regenerative mechanism?
Sorry; I know only ozone, but not oxygen, has a therapeutic effect: see a systematic review below.
Br J Pain. São Paulo, 2018 apr-jun;1(2):171-5
Ozone therapy as an integrating therapeutic in osteoartrosis treatment:
a systematic review
Ozonioterapia como terapêutica integrativa no tratamento da osteoartrose: uma revisão sistemática
Ana Paula Anzolin, Charise Dallazem Bertol
Although oxygen therapy does not create reactive oxygen species (ROS) like ozone, it exerts regenerative effects through several mechanisms:
1. Increased Oxygen Delivery: Oxygen therapy enhances the supply of oxygen to tissues, promoting cellular metabolism and supporting healing processes in damaged areas, including the knee joint.
2. Anti-inflammatory Effects: Oxygen therapy can reduce inflammation in the joint, potentially alleviating pain and promoting tissue repair without the oxidative stress associated with ROS generation.
3. Cellular Signaling: Oxygen plays a crucial role in cell signaling pathways, influencing gene expression, angiogenesis, and tissue regeneration processes essential for joint health.
4. Enhanced Collagen Production: Oxygen therapy may stimulate collagen synthesis, crucial for maintaining joint structure and function, which could aid in addressing knee joint degeneration and improving overall joint health.
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