So many reports mentioned the function of hemoglobin on ROS producction, but few reports could I found on "anti-ROS", does any researchers focus on this part. I think that is interesting to define the role of hemoglobin on redox reaction.
The role of hemoglobin as an antioxidant can be illustrated by its role in the transport of nitric oxide radical (And others) which is bound with globin (in heamglobin) by the group of thiols in the protein and can be released from him. As the process of capturing nitric oxide radical prevents it from participating in the process of forming oxidant compounds when its concentration is increased by direct or indirect method.
It also plays an antioxidant role through the process of chelating of free iron and prevent to in Fenton and Haber-Wiess reactions.
Zhihong Zheng
Dear professor Luay,
Thank you for your kindly answer. I am a Ph.D student, and I try to understand the role of hemoglobin on oxidation-antioxidation system homeostasis. I think the performance of hemoglobin for oxidation/antioxidation is dependent on different microenvironments, but less paper I could found online. If possible, can you recommend me any reports on the explaination about anti-ROS activity of hemoglobin. Thanks a lot.
Dear Zhihong Zheng ,
In fact, the available references on this subject are as follows:
Article Reactions between nitric oxide and haemoglobin under physiol...
Article Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser ...
and a book titled:
Free Radicals and Antioxidant Protocols
Editors: Uppu, R.M., Murthy, S.N., Pryor, W.A., Parinandi, N.L. (Eds.)
I hope these references will help you in what you need....
with respect
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