I seeded Vero cells on very flat surface that has silicon oxide and metal grids with no topographical surfaces. The root-mean square roughness values (obtained from AFM images) were ~0.26 ± 0.06 nm (silicon oxide) and ~0.44 ± 0.14 nm (metal). SEM images indicate that almost 95% of cells prefer metal surfaces rather than silicon oxide. does anyone have an explanation?
Hi Hassan
May I ask you what was your metallic surface?
In fact based on the type of passive layer which forms spontaneously on metallic surfaces you can interpret this phenomenon. I think there is a close relationship between cells adhesion and wettability of a surface. Usually ceramic surfaces due to the lower surface free energy exhibit higher wettabiliy compared with metals. Therefore, I suggest you to find a relationship between wettability and cell adhesion in literature.
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