A middle aged woman presented with multiple vesicular lesoins, ithy in nature over her palms, foot blisters were sterile, recurrent, it also involved the nail folds, distal end of digits, with onycolysis,

A biopsy was done and report was in favour of acrodermatitis continua. A variant of pustular psoriasis. she is being managed with a combination of isotretinoin, mehotrexate and phopttherapy with good results. when and how should the tapering of these medications be followed.